Alzheimers and Cannabis

Alzheimers is a neurodegenerative disease with no known cure.

As there is no cure for Alzheimer’s disease, the maximization of quality of patient's life is imperative.

Animal studies have shown that CBD exerts neuroprotective, antioxidant and anti-inflammatory effects. CBD also promotes neurogenesis and reverses Aβ-induced spatial memory deficits in rodents. Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice.
Cheng D, Low JK, Logge W, Garner B, Karl T.
Psychopharmacology (Berl). 2014 Aug;231(15):3009-17. doi: 10.1007/s00213-014-3478-5. Epub 2014 Mar 1.
PMID: 24577515

Beta-amyloid plaque formation in Alzheimer's disease.

Beta-amyloid plaque formation in Alzheimer's disease.
Image credit: By National Institute on Aging [Public domain], via Wikimedia Commons

Recent research has demonstrated some of the effects of THC on Alzheimers.

“Decreased levels of amyloid beta means less aggregation, which may protect against the progression of Alzheimer’s disease. Since THC is a natural and relatively safe amyloid inhibitor, THC or its analogs may help us develop an effective treatment in the future.” The potential therapeutic effects of THC on Alzheimer's disease.
Cao C, Li Y, Liu H, Bai G, Mayl J, Lin X, Sutherland K, Nabar N, Cai J.
J Alzheimers Dis. 2014;42(3):973-84. doi: 10.3233/JAD-140093.
PMID: 25024327

Study lead author Chuanhai Cao, PhD and a neuroscientist at the Byrd Alzheimer’s Institute and the USF College of Pharmacy. Marijuana compound may offer treatment for Alzheimer’s disease, USF preclinical study finds
Written by Anne DeLotto Baier · August 27, 2014 @ 10:50 am · Byrd Alzheimer's Institute, College of Pharmacy, Morsani College of Medicine, Research

Further reading

Cannabinoids in late-onset Alzheimer's disease.
PubMed: 25788394

MeSH: D000544
GeneReviews: Alzheimer Disease Overview
NICE: Dementia

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