2-arachidonoylglycerol (2-AG)

Anandamide Image Credit: PubChem Open Chemistry Database.
Molecular Formula: C23H38O4
Image credit: PubChem

2-AG is an endogenous agonist of the CB1 receptor.

2-AG is the intrinsic physiological ligand for the cannabinoid CB1 receptor. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds.
Sugiura T, Kodaka T, Nakane S, Miyashita T, Kondo S, Suhara Y, Takayama H, Waku K, Seki C, Baba N, Ishima Y.
J Biol Chem. 1999 Jan 29;274(5):2794-801.
PMID: 9915812

2-AG is an ester formed from omega-6-arachidonic acid and glycerol. Chemical Entities of Biological Interest, (also known as ChEBI)
CHEBI:52392 - 2-arachidonoylglycerol definition

2-AG is neuroprotective after brain injury. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
Panikashvili D, Simeonidou C, Ben-Shabat S, Hanus L, Breuer A, Mechoulam R, Shohami E.
Nature. 2001 Oct 4;413(6855):527-31.
PMID: 11586361

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