Cannabinol (CBN)

CBN Image Source: PubChem
Molecular Formula: C21H26O2
Image credit: PubChem

CBN is a cannabinoid isolated from Cannabis, that is a metabolite of tetrahydrocannabinol (Δ9-THC), with potential immunosuppressive and anti-inflammatory activities.

CBN preferentially binds to the cannabinoid G-protein coupled receptor CB2, which is mainly expressed on a variety of immune cells, such as T-cells, B-cells, macrophages and dendritic cells.

Stimulation of CB2 receptors by cannabinol may both trigger apoptosis in these cells and inhibit the production of a variety of cytokines. Cannabinol exerts minimal affinity for CB1 and has a weak effect on the central nervous system. Source Name: NCIt
Source ID: C84510_2949
Record Name: Cannabinol

Description: National Cancer Institute Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.

Further reading

ChemIDplus: Cannabinol
Wikipedia: Cannabinol
IUPHAR/BPS: Cannabinol
ChEMBL: Cannabinol
ZINC: Cannabinol

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