Cannabinol (CBN)

CBN Image Source: PubChem
Molecular Formula: C₂₁H₂₆O₂
Image credit: PubChem

CBN is a cannabinoid isolated from Cannabis, that is a metabolite of tetrahydrocannabinol (Δ9-THC), with potential immunosuppressive and anti-inflammatory activities.

CBN preferentially binds to the cannabinoid G-protein coupled receptor CB₂, which is mainly expressed on a variety of immune cells, such as T-cells, B-cells, macrophages and dendritic cells.

Stimulation of CB₂ receptors by cannabinol may both trigger apoptosis in these cells and inhibit the production of a variety of cytokines. Cannabinol exerts minimal affinity for CB₁ and has a weak effect on the central nervous system. Source Name: NCIt
Source ID: C84510_2949
Record Name: Cannabinol
URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C84510
Description: National Cancer Institute Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.

Cannabinol (CBN)

Further reading