Cannabichromene (CBC)

CBC Image Source: PubChem
CBC Molecular Formula: C21H30O2
Image credit: PubChem
CBC is a naturally occuring cannabinoid and non-psychoactive constituent of Cannabis sativa L. CBC does not affect the psychoactivity of THC. Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids.
Ilan AB, Gevins A, Coleman M, ElSohly MA, de Wit H.
Behav Pharmacol. 2005 Sep;16(5-6):487-96.
PMID: 16148455

CBC has been shown to induce analgesia and modulate the pathway of antinociception. Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action.
Maione S, Piscitelli F, Gatta L, Vita D, De Petrocellis L, Palazzo E, de Novellis V, Di Marzo V.
Br J Pharmacol. 2011 Feb;162(3):584-96. doi: 10.1111/j.1476-5381.2010.01063.x. PMID: 20942863

CBC has been shown to exert antidepressant-like effects. Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.
El-Alfy AT, Ivey K, Robinson K, Ahmed S, Radwan M, Slade D, Khan I, ElSohly M, Ross S.
Pharmacol Biochem Behav. 2010 Jun;95(4):434-42. doi: 10.1016/j.pbb.2010.03.004. Epub 2010 Mar 21.
PubMed PMID: 20332000

CBC has been shown to decrease inflammation. Anti-inflammatory activity of cannabichromene homologs.
Wirth PW, Watson ES, ElSohly MA, Seidel R, Murphy JC, Turner CE.
J Pharm Sci. 1980 Nov;69(11):1359-60. No abstract available.
PMID: 7452475

Further reading

ChemIDplus #20675-51-8
ChemSpider #28064
ChEBI #3357

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