Lysophosphatidylinositol (LPI)
LPI is a proposed natural ligand and agonist of GPR55.1 LPI has recently been associated with mediating ovarian carcinoma cell-induced angiogenesis.
The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis.
Hofmann NA, Yang J, Trauger SA, Nakayama H, Huang L, Strunk D, Moses MA, Klagsbrun M, Bischoff J, Graier WF.
Br J Pharmacol. 2015 Aug;172(16):4107-18. doi: 10.1111/bph.13196. Epub 2015 Jun 26.
PMID: 25989290
Growing evidence points to a role of lysophosphatidylinositol (LPI) in cancer.
L-α-lysophosphatidylinositol meets GPR55: a deadly relationship.
Ross RA.
Trends Pharmacol Sci. 2011 May;32(5):265-9. doi: 10.1016/j.tips.2011.01.005. Epub 2011 Mar 1.
PMID: 21367464
External links
ChemIDplus #lysophosphatidylinositol
WikiPedia
IUPHAR/BPU #4028
MeSH
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