2-arachidonyl-glyceryl ether (2-AGE)
Molecular Formula: C23H40O3
Image credit: PubChem
2-AGE is an endogenous agonist for the GPR55 and CB1 receptors that displays selectivity over CB2 receptors.
2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.
Hanus L, Abu-Lafi S, Fride E, Breuer A, Vogel Z, Shalev DE, Kustanovich I, Mechoulam R.
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3662-5. Epub 2001 Mar 20.
2-AGE markedly increased efforts expended by animals to obtain food. 2-AGE exerts a specific action on eating motivation; possibly promoting eating by increasing the incentive value of food.
Noladin ether, a putative endocannabinoid, enhances motivation to eat after acute systemic administration in rats.
Jones EK, Kirkham TC.
Br J Pharmacol. 2012 Jul;166(6):1815-21.
2-AGE is also called Noladin Ether.