2-arachidonyl-glyceryl ether (2-AGE)

Anandamide Image Credit: PubChem Open Chemistry Database.
Molecular Formula: C23H40O3
Image credit: PubChem

2-AGE is an endogenous agonist for the GPR55 and CB1 receptors that displays selectivity over CB2 receptors. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.
Hanus L, Abu-Lafi S, Fride E, Breuer A, Vogel Z, Shalev DE, Kustanovich I, Mechoulam R.
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3662-5. Epub 2001 Mar 20.
PMID: 11259648

2-AGE markedly increased efforts expended by animals to obtain food. 2-AGE exerts a specific action on eating motivation; possibly promoting eating by increasing the incentive value of food. Noladin ether, a putative endocannabinoid, enhances motivation to eat after acute systemic administration in rats.
Jones EK, Kirkham TC.
Br J Pharmacol. 2012 Jul;166(6):1815-21.
doi: 10.1111/j.1476-5381.2012.01888.x.
PMID: 22309979

2-AGE is also called Noladin Ether.

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