Cannabinol (CBN)
Molecular Formula: C21H26O2
Image credit: PubChem
CBN is a cannabinoid isolated from Cannabis, that is a metabolite of tetrahydrocannabinol (Δ9-THC), with potential immunosuppressive and anti-inflammatory activities.
CBN preferentially binds to the cannabinoid G-protein coupled receptor CB2, which is mainly expressed on a variety of immune cells, such as T-cells, B-cells, macrophages and dendritic cells.
Stimulation of CB2 receptors by cannabinol may both trigger apoptosis in these cells and inhibit the production of a variety of cytokines. Cannabinol exerts minimal affinity for CB1 and has a weak effect on the central nervous system.
Source Name: NCIt
Source ID: C84510_2949
Record Name: Cannabinol
URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C84510
Description: National Cancer Institute Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.
Further reading
ChemIDplus: Cannabinol
Wikipedia: Cannabinol
IUPHAR/BPS: Cannabinol
ChEMBL: Cannabinol
ZINC: Cannabinol