Cannabidiolic acid (CBDA)

Molecular Formula: C₂₂H₃₀O₄
Image credit: PubChem

CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers. Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H.
Toxicol Lett. 2012 Nov 15;214(3):314-9. doi: 10.1016/j.toxlet.2012.08.029. Epub 2012 Sep 8.
PMID: 22963825

CBDA is produced by the oxidocyclization of cannabigerolic acid(CBGA) by CBDA synthase. Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid.
Taura F, Morimoto S, Shoyama Y.
J Biol Chem. 1996 Jul 19;271(29):17411-6.
PMID: 8663284

CBDA also prevents nausea-induced behavior in rats by enhancing the activation of the serotonin 5-HT1A receptor. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation.
Bolognini D, Rock EM, Cluny NL, Cascio MG, Limebeer CL, Duncan M, Stott CG, Javid FA, Parker LA, Pertwee RG.
Br J Pharmacol. 2013 Mar;168(6):1456-70. doi: 10.1111/bph.12043.
PMID: 23121618